These medicines may or may not be reimbursed by social security agencies. The other drugs are said to be optional medical prescription, ie they can be prescribed by a doctor or advised by the pharmacist. In order to be marketed, a medicinal product must obtain a Marketing Authorization (MA) issued either by the Director General of the National Agency for the Safety of Medicines and Health Products (ANSM) or by the European Commission after evaluation by the Committee for Medicinal Products for Human Use (CHMP) of the European Agency for the Evaluation of Medicinal Products (EMA).